Gene annotation is the process of assigning meaning to different parts of a sequenced genome. The process of annotation involves using a combination of computational and experimental evidence to identify features of genes within DNA sequences. Due to the complexity and diversity of gene structure, human-curated gene analysis has been shown to be significantly more accurate than computational approaches. This comparative genomics project involved collecting, analyzing, and synthesizing evidence comparting D. bipectinata to the well-characterized model organism D. melanogaster to created best-supported gene “models” in this newly sequenced species. The application of this research lies in the use of Drosophila comparative genomics to understand the organization, evolution and gene function of the F element, a unique heterochromatic domain in fruit flies.
Belachew, Yordanos and Justice, Sarah, "Gene Annotation & the Genomics Education Partnership (GEP)" (2021). Faculty-Mentored Undergraduate Scholarship. 3.